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Volume 1, Number 4 – December, 2002 |
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The following articles appeared in the December issues of the surveyed journals. Articles that seem to be of most interest to the practicing gynecologic oncologist are included. The journals that are surveyed are New England Journal of Medicine, Journal of Clinical Oncology, Gynecologic Oncology, Cancer, American Journal of Obstetrics and Gynecology, Lancet, Cancer Research, Obstetrics and Gynecology, Journal of the National Cancer Institute, Journal of the American Medical Association. The participants in this program are the active clinical fellows at Memorial Hospital: Bhavana Pothuri, Mario Leitao, Christopher Awtrey, Sarah Ferguson, Alan Schlaerth and Rami Eitan. The managing editor is Douglas Levine. Comments, questions, complaints and suggestions are always welcome, please E-mail us at: VJC@smgo.org or click here. To subscribe or unsubscribe to the VJC, click here. Gynecologic Oncology – Mario Leitao Title: Should the Presence of Lymphvascular Space Involvement Be Used to Assign Patients to Adjuvant Therapy Following Hysterectomy for Unstaged Endometrial Cancer? Authors: David E. Cohn, Neil S. Horowitz, David G. Mutch, Seok-Mo Kim, Tom Manolitsas and Jeffrey M. Fowler Source: Gynecologic Oncology, Volume 87, Issue 3, December 2002, Pages 243-246. Summary: Retrospective review of 366 patients with surgically staged endometrial adenocarcinoma. When controlled for both grade and depth of invasion together, LVSI predicted pelvic lymph node metastasis for deeply invasive tumors. Multivariate analysis revealed that LVSI and depth of invasion were independent predictors of pelvic lymph node metastasis. This study reviews a large number of cases but the subset analyses led to small numbers in each cell. This study does not suggest that LVSI confers a worse survival but states that it is a predictor for lymph node metastasis. Click here for abstract from Gynecologic Oncology Title: Surgical Stage I Endometrial Cancer: Predictors of Distant Failure and Death Authors: Andrea Mariani, Maurice J. Webb, Gary L. Keeney, Timothy G. Lesnick and Karl C. Podratz Source: Gynecologic Oncology, Volume 87, Issue 3, December 2002, Pages 274-280. Summary: Retrospective review of 229 patients with surgical stage I node-negative endometrial carcinoma. Reports that outer 1/3 myometrial invasion is a significant risk factor for distant failure and death. The authors call for more randomized trials of adjuvant therapy in node-negative patients with deep myometrial invasion. Click here for abstract from Gynecologic Oncology Journal of Clinical Oncology - Bhavana Pothuri Nothing of interest this month Journal of the National Cancer Institute – Rami Eitan Title: Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers Authors: Steven A. Narod et al. Source: J Natl Cancer Inst 2002;94:1773-9. Summary: To examine the association between oral contraceptive use and breast cancer in BRCA mutation carrying women the authors performed a case-control study on 1311 pairs of women with BRCA 1 or 2 mutations. Among BRCA2 carriers ever use of OC was not associated with an increased risk of breast cancer. For BRCA1 carriers ever use was associated with a modestly increased risk (OR=1.2). Those who used OC 5 years or more had an increased risk (OR=1.33), as did those who used OC before age 30 (OR=1.29), were diagnosed with breast cancer before age 40 (OR=1.38), or used OC before 1975 (OR=1.42). The authors concluded that among BRCA1 mutation carriers, women who used OC before 1975, used them before age 30, or for more than 5 years have an increased risk of early onset breast cancer. Click here for abstract from JNCI Obstetrics and Gynecology – Alan Schlaerth Title: Local relapse in patients treated for squamous cell vulvar carcinoma: Incidence and prognostic value Authors: Roman Rouzier, Bassam Haddad, Francoise Plantier, Philippe Dubois, Monique Pelisse and Bernard-Jean Paniel Source: Obstetrics & Gynecology, Volume 100, Issue 6, December 2002, Pages 1159-1167. Summary: This retrospective study of 215 patients with squamous cell vulvar carcinoma evaluated risk factors for local relapse and its impact on survival. The greatest risk factor for local relapse was margin status followed by depth of invasion. Vulvar skin bridge or primary tumor site recurrences were strong predictors of cancer related death, whereas, recurrence distant from the primary tumor site was not a strong predictor. Click here for abstract from Obstetrics & Gynecology Title: The factor V Leiden mutation and the risk of venous thromboembolism in gynecologic oncology patients Authors: Amy J. Ravin, Robert P. Edwards, Marijane A. Krohn, Joseph R. Kelley, Wayne A. Christopherson and James M. Roberts Source: Obstetrics & Gynecology, Volume 100, Issue 6, December 2002, Pages 1285-1289. Summary: This case-control study measured the association of Factor V Leiden mutation and venous thromboembolism in 74 gynecologic cancer patients. The investigators found that the factor V Leiden mutation does not play a significant role in the risk of venous thromboembolism in these patients (odds ratio 0.3, 95%CI 0.1, 1.7). The high risk of venous thromboembolism in gynecologic oncology patients is attributed more to their cancer and treatment, than to an inherited predisposition to thrombosis. Click here for abstract from Obstetrics & Gynecology American Journal of Obstetrics and Gynecology – Chris Awtrey Nothing of interest this month New England Journal of Medicine – Bhavana Pothuri Nothing of interest this month Journal of the American Medical Association – Rami Eitan Nothing of interest this month Cancer – Sarah Ferguson Nothing of interest this month Lancet – Chris Awtrey Nothing of interest this month Cancer Research – Sarah Ferguson Nothing of interest this month |
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